University of Southern California
Ray R. Irani Hall
Molecular and Computational Biology
Seminar Series
Jun O. Liu
Dept. of Pharmacology
Johns Hopkins University
School of Medicine
“Discovery and Mechanistic Studies of Novel Inhibitors of Angiogenesis
from the Johns Hopkins Drug Library”
Abstract:
Small chemical ligands can serve as both molecular probes for studying different biological processes and leads for drug development. To discover novel chemical ligands, we have built a library of mostly clinical drugs, called the Johns Hopkins Drug Library (JHDL). We have screened JHDL in multiple assays including endothelial cell proliferation assay in search for inhibitors of angiogenesis. We have found several known drugs with previously unappreciated anti-angiogenic activity. Subsequent mechanistic studies have led to new insights into the functions of the targets of the inhibitors. Preclinical evaluations revealed that these inhibitors are efficacious in blocking angiogenesis and tumor growth in vivo, paving the way for these inhibitors to enter human clinical trials.
FRIDAY, April 23, 2010
12:00 noon
RRI 101
Host: Lin Chen
